• WordNet 3.6
    • n myxedema hypothyroidism marked by dry skin and swellings around lips and nose as well as mental deterioration
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Century Dictionary and Cyclopedia
    • n myxedema A disease having the following characters: An increase and degeneration of connective tissue over the body, so that it yields an extraordinary quantity of mucin, and hence an edematoid condition of the skin, which does not, however, pit on pressure. This is accompanied by dystrophy of epidermic structures and failure of dermal secretions; anæsthesia, paresthesiac neuralgias, and digestive troubles also are complained of.
    • n myxedema It has been found that this affection is usually entirely amenable to treatment by extracts and other preparations made from the thyroid gland (throat-sweetbread) of the sheep. The same treatment is often of great value in cretinism, which is regarded as a congenital form of myxedema. The use of preparations of the thyroid gland to supply a deficiency of the secretion of this gland, which is the underlying defect in myxedema and cretinism, affords one of the most brilliant examples of successful organotherapy.
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In literature:

Myxedema proper is a constitutional condition due to the loss of the function of the thyroid gland.
"Anomalies and Curiosities of Medicine" by George M. Gould
If the thyroid gland was at fault we would have either the low mentality commonly spoken of as cretinism, or myxedema.
"The Goat-gland Transplantation" by Sydney B. Flower