telomere

Definitions

  • WordNet 3.6
    • n telomere either (free) end of a eukaryotic chromosome "telomeres act as caps to keep the sticky ends of chromosomes from randomly clumping together"
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Usage

In literature:

Eventually the telomeres become so short that all cell division stops.
"Syndrome" by Thomas Hoover
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In news:

"Two" Much of a Good Thing: Telomere Damage-Induced Genome Doubling Drives Tumorigenesis p712.
Cerevisiae Tel1p and Mre11p Are Required for Normal Levels of Est1p and Est2p Telomere Associatio.
Telomerase and Tel1p Preferentially Associate with Short Telomeres in S. Cerevisiae Tel1p and Mre11p Are Required for Normal Levels of Est1p and Est2p Telomere Associatio.
Telomeres and Mitochondria in the Aging Heart Moslehi et al.
Short Telomeres and Prognosis of Hypertension in a Chinese Population Yang et al.
Telomeres are repetitive, noncoding sequences that cap the ends of linear chromosomes.
Investigating telomeres and what they mean for aging -related diseases.
Preston Estep discusses the role that telomeres play in the aging process.
Investigating telomeres and what they mean for aging-related diseases.
DNA 'Telomere' Length Tied to Aging, Death Risk.
Women tend to have longer telomeres than men and tend to outlive men, according to new research matching genetic information with medical records.
Investigating telomeres and what they mean for aging-related diseases.
Balancing our fatty acids is associated with longer telomeres -- the things that protect our chromosomes from breaking down.
Add this to the approximately 8 billion benefits of omega-3 fatty acids: They could help preserve DNA segments known as telomeres, whose degradation is a key marker of aging.
The test measures telomeres, structures on the end of each of your chromosomes, which scientists think may hold the key to determining a person's "true age.".
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In science:

Mangel, Growth, telomere dynamics, and successful and unsuccessful human aging.
Evolutionary ecology in-silico: Does mathematical modelling help in understanding the "generic" trends?
Although the nucleation step is different in telomeric silencing, the process of spreading seems to be very similar .
Epigenetic Chromatin Silencing: Bistability and Front Propagation
Most importantly, telomeres have a stabilizing effect on the DNA.
The Aldous-Shields model revisited (with application to cellular ageing)
The DNA repair mechanism of a cell must be able to distinguish between usual DNA breaks (which it is assumed to repair) and the telomeres (which it is assumed to ignore).
The Aldous-Shields model revisited (with application to cellular ageing)
It can be observed that telomeres shrink from 15 kilobases at birth to less than 5 kilobases during a lifetime ().
The Aldous-Shields model revisited (with application to cellular ageing)
However, the enzyme telomerase is known to be able to decrease the loss of telomeres during replication.
The Aldous-Shields model revisited (with application to cellular ageing)
The model by was extended in several directions. A stochastic amount of loss of telomeres was studied in .
The Aldous-Shields model revisited (with application to cellular ageing)
In , a model is proposed which distinguishes two states of telomeres: capped and uncapped.
The Aldous-Shields model revisited (with application to cellular ageing)
In stem and tumor cells, telomerase is (among other things) responsible for transitions from uncapped back to capped telomeres.
The Aldous-Shields model revisited (with application to cellular ageing)
In stem cells, the decreasing rate for an uncapped telomere to reeneter the capped state for shorter telomeres from shows exactly the behaviour of the Aldous-Shields model: cells with a long replicative history proliferate slower.
The Aldous-Shields model revisited (with application to cellular ageing)
While use a linear decrease in replication rate, depending on telomere length, the Aldous-Shields model uses a geometric decay of the proliferation rate.
The Aldous-Shields model revisited (with application to cellular ageing)
Note that short telomeres can be seen as a form of damage.
The Aldous-Shields model revisited (with application to cellular ageing)
If a cell is in generation h + 1 from the mother cell, its telomeres have reached the Hay´Čéick limit and the cell is not able to proliferate any more.
The Aldous-Shields model revisited (with application to cellular ageing)
Mathematical modeling of the loss of telomere sequences. J.
The Aldous-Shields model revisited (with application to cellular ageing)
Stabilization of telomeres in nonlinear models of proliferating cell lines. J.
The Aldous-Shields model revisited (with application to cellular ageing)
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