metabolite

Definitions

  • WordNet 3.6
    • n metabolite any substance involved in metabolism (either as a product of metabolism or as necessary for metabolism)
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Webster's Revised Unabridged Dictionary
    • n Metabolite (Physiol Chem) A product of metabolism; a substance produced by metabolic action, as urea.
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Century Dictionary and Cyclopedia
    • n metabolite A product of or substance resulting from metabolism, especially from retrograde metabolism, or catabolism.
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Usage


In news:

Hca extract is just not adequately known, however it is wildly popular inside Europe and it is developing inside recognition from the United states, because it is found in several different weight loss supplements including Metabolite Super.
An overview of applications in the analysis of nutrients and metabolites.
When the team further characterized dysregulated metabolites in the dorsal horn tissue, they identified multiple alterations in sphingomyelin-ceramide metabolism 21 days after TNT injury.
Mass spectrometry is a key analytical tool used for metabolism studies because it can identify the metabolites and the sites at which metabolism occurs.
Major League Baseball suspended Mets farmhand Hengelbert Rojas for 50 games without pay for a positive test for metabolites of Stanozolol and Nandrolone.
Indians minor league catcher Steven Lebron was suspended for 50 games for testing positive for the steroid Boldenone metabolite.
Now it appears as if 8-hydroxyefavirenz, one of the metabolites created when efavirenz is metabolized by the liver, can damage important "dendritic spines" of neurons —the cells' critical information processing points.
Upregulated Metabolite May Be Target for Neuropathic Pain Therapy.
Antimetabolites are structural analogs of the naturally occurring metabolites involved in DNA and RNA synthesis.
It can be thought of as an extra sequence on MRI, such as FLAIR, but with actual metabolite data.
Acetaminophen causes oxidative damage to erythrocytes and hepatocytes as the result of a toxic metabolite that binds to glutathione.
N -Acetylcysteine provides sulfydryl groups that act as a substitute for glutathione and bind with the toxic metabolite, decreasing the oxidative damage to the cells.
INF Freddy Galvis, Philadelphia, June 19, 50 games (clostebol metabolite).
"Ultimately, what would be ideal is if we could determine a set of metabolite or small molecule markers from the barley that were correlated with beer quality," says Prenni.
Chemotaxonomy Based on Metabolites from Glandular Trichomes.
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In science:

For example, the degree distribution of the metabolites in these networks has a power law tail [10,11]. Metabolic networks seem to have further remarkable features such as a high level of clustering . However, to claim that such features are remarkable, one has to use a benchmark.
Randomizing genome-scale metabolic networks
KEGG_Hybrid reaction set We have used a hybrid database compiled by Rodrigues and Wagner containing 4816 metabolites and 5870 biochemical reactions for this work.
Randomizing genome-scale metabolic networks
The in- and outdegree distributions for reaction and metabolite nodes are chosen to be Poisson with average degree 1.5 and 3.75, respectively.
A weighted message-passing algorithm to estimate volume-related properties of random polytopes
Powell W. S. (1982) Rapid extraction of arachidonic acid metabolites from biological samples using octadecylsilyl silica.
Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats
Recently, Inouye et al. (2012) tested each SNP individually with groups of phenotypes, where the phenotype groups corresponded to clusters of highly correlated metabolites.
Genome-wide association studies with high-dimensional phenotypes
As the phenotype, we use all the metabolites jointly; in the simulations we additionally consider analysing only a subset of highly correlated metabolites at a time.
Genome-wide association studies with high-dimensional phenotypes
With smaller numbers of simulated phenotypes, the affected traits were selected analogously such that they corresponded to some correlated subclass of the real metabolites. (5) The effect sizes were drawn randomly from the interval [0.75bmax , bmax ], where bmax is the value reported in Results.
Genome-wide association studies with high-dimensional phenotypes
This is due to the fact that CCA-single gives a single p-value jointly for all metabolites, while PEER uses the smallest p-value over the metabolites.
Genome-wide association studies with high-dimensional phenotypes
Although with the LD-block shown in the Figure 3 the scores from PEER and CCA-single are highly correlated (presumably due to the strong associations between the SNPs and the metabolites), this did not happen in general with LD-blocks with known causal SNPs.
Genome-wide association studies with high-dimensional phenotypes
This indicates that when not only the metabolites, but also the SNPs are tested jointly in CCA-block, only those SNPs from a group of correlated SNPs get high scores that are most associated with the phenotype traits.
Genome-wide association studies with high-dimensional phenotypes
Other SNPs with reported associations with metabolite traits (from dbSNP, Sherry et al., 2001) are shown with blue vertical lines (solid if SNP was included in our data, dotted otherwise).
Genome-wide association studies with high-dimensional phenotypes
As the basis of simulating the phenotypes we used the empirical correlation matrix of IDL (6 features) or VLDL (31 features) metabolite subgroups.
Genome-wide association studies with high-dimensional phenotypes
Figure 5: Power of different methods in the metabolite subgroup simulation scenario.
Genome-wide association studies with high-dimensional phenotypes
High residual correlation corresponds to using the empirical correlation matrix of a speci fic group of highly correlated metabolites to simulate the noise.
Genome-wide association studies with high-dimensional phenotypes
The set of stoichiometric interactions in the cell can be represented as a network whose nodes are of two types, the metabolic substrates of metabolites and the nodes representing the reactions.
Flux distribution in metabolic networks close to optimal biomass production
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