• WordNet 3.6
    • n histone a simple protein containing mainly basic amino acids; present in cell nuclei in association with nucleic acids
    • ***


In news:

Centromere Silencing and Function in Fission Yeast Is Governed by the Amino Terminus of Histone H3.
Cis-Acting DNA from Fission Yeast Centromeres Mediates Histone H3 Methylation and Recruitment of Sil.
Centromere Silencing and Function in Fission Yeast Is Governed by the Amino Terminus of Histone H3.
One element involved in regulation of gene expression is modification of nearby histones (proteins around which DNA is wrapped).
The proposed research will investigate whether histones near genes of interest are specifically regulated in a nutrient-responsive manner.
PrognosDx and Accium to Work on Histone Biomarker Cancer Tests.
Ltd.'s investigational therapy, Pracinostat, an oral histone deacetylase (HDAC) inhibitor with potential to be best-in-class.
The AbSurance™ arrays comprise 89 synthetic modified and unmodified peptides based on human histone protein sequences.
Histone Deacetylases Associated with the mSin3 Corepressor Mediate Mad Transcriptional Repression.
Histone deacetylase inhibitors such as vorinostat are safe and efficacious in combination with standard first-line chemotherapy in acute myelogenous leukaemia (AML) or myelodysplastic syndrome (MDS) according to a new phase 2 study.
Michael Histon driving the tractor with the chefs behind him.
The targeted therapies used to treat leukemias and lymphomas include monoclonal antibodies, tyrosine kinase inhibitors, histone deacetylase inhibitors, hypermethylation inhibitors, and proteasome inhibitors.

In science:

The diploid human genome consists of about 2 m of double stranded DNA, which is wrapped around histone protein octamers, forming nucleosomes every 180 to 250 bp.
A Random Loop Model for Long Polymers
The first stages of compaction are well-known (see ref. for a review): The DNA double strand is wrapped around histone octamers in a 1-and3/4 left-handed superhelical turn forming the so-called nucleosomes, which are connected by stretches of linker DNA.
A Random Loop Model for Long Polymers
This decision would be determined by the presence in the embryo cells of certain chemicals in asymmetrical quantities and would then be “stored” in the nucleus through changes in the histone-arginine methylation patterns of specific DNA segments.
Epigenetic Tracking, a Method to Generate Arbitrary Shapes By Using Evolutionary-Developmental Techniques
However, CROGIDs do have one advantage over NCBI Gene IDs in that they are protein-based and hence identical protein products of several genes (like histones) are clustered together.
ppiTrim: Constructing non-redundant and up-to-date interactomes
In the general model, there is usually a region that nucleates silencing by recruiting a silencing complex incorporating a histone modifying enzyme (figure 1).
Epigenetic Chromatin Silencing: Bistability and Front Propagation