acetylate

Definitions

  • WordNet 3.6
    • v acetylate introduce an acetyl group into (a chemical compound)
    • v acetylate receive substitution of an acetyl group "the compounds acetylated"
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Century Dictionary and Cyclopedia
  • Interesting fact: The name Aspirin was invented from "A" in acetyl chloride. The "spir" comes from spiraea ulmaria which is the plant that they got the salicylic acid from, and the "in" was used because back then it was popular to end the name of medicines with "in."
    • acetylate To introduce the acetyl group into; especially, to prepare an acetyl derivative of an organic compound containing a hydroxyl- or amino-group.
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Usage

In literature:

And what about Acetyl-Salicylic, And what of Calomels and Soda Sals?
"Punch, or the London Charivari, Vol. 159, August 25th, 1920" by Various
If this hydrate survived the acetylation it would of course affect the empirical composition, i.e.
"Researches on Cellulose" by C. F. Cross
The acetyl-derivative of aniline and of methylaniline are febrifuges known as "antifebrine" and "exalgine.
"Coal" by Raphael Meldola
They form acetyl esters, or acetates, which can be separated from each other and identified by their crystal forms and melting points.
"The Chemistry of Plant Life" by Roscoe Wilfred Thatcher
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In news:

How to read the Hun's letter without noticeably opening it: mix copper acetyl arsenic with three ounces acetone.
Acetyl Hexapeptide-3: Smoothing , Wrinkling, and Protecting Skin Around The World.
Nutrients, including vitamins E and B12, and molecules such as SAM-e (S-adenosylmethionine) N-acetyl L-cysteine and Acetyl L-carnitine, are important to cognition and a healthy brain.
Lightening and Illuminating Skin With Acetylated Hydroxystilbenes From Rheum rhaponticum.
Lightening and Illuminating Skin With Acetylated Hydroxystilbenes From Rheum rhaponticum CosmeticsAndToiletries.com.
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In science:

For example, one may wish to treat interactions arising from enzymatic reactions as directed and to be able to selectively include/exclude certain types of reactions such as acetylation.
ppiTrim: Constructing non-redundant and up-to-date interactomes
One such example is a mutation that reduces the rate of background acetylation of particular histone side-chains that competes with the deacetylation by Sir2p.
Epigenetic Chromatin Silencing: Bistability and Front Propagation
Epigenetic states, in the absence of efficient nucleation, can be explained as a consequence of the existence of two stable uniform static solutions: the hyper-acetylated state and silenced states on DNA.
Epigenetic Chromatin Silencing: Bistability and Front Propagation
The main variables involved in final equations are the local degree of acetylation and the local probability of occupation by Sir complex, both of which could depend on time, as well as on the position of nucleosomes on DNA, represented as a one-dimensional lattice.
Epigenetic Chromatin Silencing: Bistability and Front Propagation
Fractional degree of acetylation, Ai (t), is defined in the same way too.
Epigenetic Chromatin Silencing: Bistability and Front Propagation
The parameter α represents the constant acetylation rate‡.
Epigenetic Chromatin Silencing: Bistability and Front Propagation
More generally, the acetylation rate could be α(1 − Ai )(1 + σ − Si ) allowing acetylation of histones in silencing complex bound nucleosomes, but adding this process does not make a qualitative difference.
Epigenetic Chromatin Silencing: Bistability and Front Propagation
Transcription of a gene is often associated with a higher rate of acetylation of histone tails.
Epigenetic Chromatin Silencing: Bistability and Front Propagation
One might therefore imagine that silencing, which affects local transcription rates, indirectly affects the local acetylation rate.
Epigenetic Chromatin Silencing: Bistability and Front Propagation
One way to model this is to introduce an additional function g (1 − Si ) in the local acetylation rate making it α(1 − Ai (t))(1 − Si (t))g (1 − Si (t)).
Epigenetic Chromatin Silencing: Bistability and Front Propagation
Note that the critical point of this bifurcation is at low availability silencing factors coupled with low rate of acetylation.
Epigenetic Chromatin Silencing: Bistability and Front Propagation
If we are in the upper half of the bistable region (Region I in figure 4), high acetylation rate makes difficult for silenced region to spread into the unsilenced region.
Epigenetic Chromatin Silencing: Bistability and Front Propagation
Independent of where the wild type yeast is located in parameter space, we could discuss the consequences of lowering the acetylation rate as it happens in, say, the sas2 mutant [25, 26].
Epigenetic Chromatin Silencing: Bistability and Front Propagation
If the reduced acetylation rate in sas2 mutant is within a certain range, the system will always flow back closer to the cusp point at the tip of the bistable region thanks to Sir titration effects.
Epigenetic Chromatin Silencing: Bistability and Front Propagation
To analyze single cell data, one needs to know not only how the deterministic model behaves but also how noise in various quantities affects expression. A stochastic version of the model, a lattice model with local states of acetylation, and Sir occupancy, could be studied by direct simulation.
Epigenetic Chromatin Silencing: Bistability and Front Propagation
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