Cox-2 inhibitor

Definitions

  • WordNet 3.6
    • n Cox-2 inhibitor an anti-inflammatory drug that fights pain and blocks Cox-2 activity without impeding the activity of Cox-1; increases the risk of heart attacks "Cox-2 inhibitors reduce the symptoms of arthritis without endangering the stomach and kidneys"
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Usage


In science:

Prostaglandin E2 concentrations in the ischemic cortex are reduced by nimesulide but not by the COX-1 inhibitor VAS We investigated the effect of selective inhibition of either COX-1 or COX-2 on PGE2 levels in the ischemic cerebral cortex after 24 h of reperfusion.
Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats
Administration of the COX-2 inhibitor nimesulide produced a significant protective effect against ischemia-induced PGE2 accumulation in the cerebral cortex, keeping PGE2 concentrations at the basal level (compared to ipsilateral side of sham-operated animals).
Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats
The selective COX-1 inhibitor VAS showed no effect on ischemia-induced leukocyte infiltration and edema (Table 2).
Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats
However, nimesulide is not a highly selective COX-2 inhibitor.
Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats
The wide therapeutic time window of protection of COX-2 inhibitors in ischemic stroke has very important implications in the clinical practice.
Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats
Elucidation of these mechanisms could explain, in part, the neuroprotective efficacy of COX-2 inhibitors in animal models of stroke, as demonstrated by several research groups.
Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats
In summary, the present study sheds additional light on the neuroprotective effects of the COX-2 inhibitor nimesulide against ischemia-induced PGE2 formation, BBB damage, leukocyte infiltration, and vasogenic edema in a rat model of transient focal cerebral ischemia.
Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats
Sugimoto K. and Iadecola C. (2003) Delayed effect of administration of COX-2 inhibitor in mice with acute cerebral ischemia.
Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats
Production of PGE2 in the ischemic cerebral cortex is potently reduced by the COX-2 inhibitor nimesulide, but only very modestly diminished by the highest dose of the COX-1 inhibitor valeryl salicylate (VAS).
Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats
Given the potent neuroprotection observed with nimesulide at a dose of 12 mg/kg, we decided to select this dose for subsequent experiments evaluating the therapeutic window of protection of this COX-2 inhibitor.
Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat
This study demonstrated that the COX-2 inhibitor nimesulide appreciably reduces cerebral infarction, PGE2 accumulation, and also improves functional outcome after transient MCAO in rats.
Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat
Prasit, C.C. Chan, Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor, Br. J.
The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils
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